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Liquiritigenin introduction

Liquiritigenin is one of the main bioactive components extracted from licorice.

Because of the high-value pharmacological activities, it serves as an intermediate for the synthesis of drugs with anti-diabetic, anti-tuberculosis and other properties, offering significant potential and vast application prospects in the healthcare field.

Two targets and two pathways

We selected allosteric transcription repressor factor FdeR and a riboswitch that identify naringenin as starting points, and used error-prone PCR, site-directed mutation, and phage-assisted continuous evolution (PACE) strategies enabling them to specifically recognize naringenin.

Transcription Factor

Riboswitch

error-prone PCR

&

site-directed mutagenesis

Fluorescence activated Cell Sorting