@font-face {
  font-family: 'Alegreya';
  src: url('../static/fonts/Alegreya-VF-latin.woff2') format('woff2');
  font-weight: 400 900;
  font-style: normal;
  font-display: swap;
}

@font-face {
  font-family: 'Alegreya';
  src: url('../static/fonts/Alegreya-Italic-latin.woff2') format('woff2');
  font-weight: 400 900;
  font-style: italic;
  font-display: swap;
}

@font-face {
  font-family: 'Bitter';
  src: url('../static/fonts/Bitter-latin.woff2') format('woff2');
  font-weight: 400 900;
  font-style: normal;
  font-display: swap;
}



.doc-container {
  max-width: 1280px;
  margin-inline: auto;
  padding-inline: clamp(20px, 4vw, 48px);
}

.doc-hero {
  
  padding-top: calc(var(--nav-h) + clamp(28px, 4vw, 56px));
  padding-bottom: clamp(48px, 6vw, 88px);
}

.doc-title {
  font-size: clamp(3.25rem, 7vw, 5rem);
  font-weight: var(--fw-black);
  letter-spacing: -0.03em;
  line-height: 1.08;
  margin-bottom: var(--s-4);
}

.doc-hero-lead {
  font-size: clamp(1.05rem, 1.6vw, 1.2rem);
  font-weight: var(--fw-light);
  color: var(--color-text-tertiary);
  line-height: 1.65;
  max-width: 680px;
}

.doc-meta {
  display: flex;
  flex-wrap: wrap;
  gap: var(--s-2) var(--s-5);
  margin-top: var(--s-5);
  font-size: var(--fs-xs);
  font-weight: var(--fw-semibold);
  letter-spacing: 0.14em;
  text-transform: uppercase;
  color: var(--color-highlight);
}

.doc-meta span { display: inline-flex; align-items: center; gap: var(--s-2); }
.doc-meta span::before {
  content: '';
  width: 5px;
  height: 5px;
  border-radius: 50%;
  background: var(--color-highlight);
}



.doc-layout {
  display: grid;
  grid-template-columns: 232px minmax(0, 1fr);
  gap: clamp(48px, 6vw, 96px);
  align-items: start;
  padding-bottom: var(--s-9);
}

.doc-article {
  max-width: 720px;
  min-width: 0;

  
  font-family: 'Alegreya', Georgia, 'Times New Roman', serif;
  color: #000;
}



.doc-toc {
  position: sticky;
  top: calc(var(--nav-h) + 40px);
  max-height: calc(100vh - var(--nav-h) - 64px);
  overflow-y: auto;
  overscroll-behavior: contain;
  scrollbar-width: thin;
}

.doc-toc-label {
  font-size: var(--fs-sm);
  font-weight: var(--fw-semibold);
  text-transform: uppercase;
  letter-spacing: 0.2em;
  color: #000;
  margin-bottom: var(--s-4);
}

.doc-toc-list {
  list-style: none;
  border-left: 5px solid var(--color-border-light);
}

.doc-toc-item { margin: 0; }

.doc-toc-link {
  display: block;
  padding: var(--s-2) 0 var(--s-2) var(--s-4);
  margin-left: -5px;
  border-left: 5px solid transparent;
  font-family: 'Alegreya', Georgia, 'Times New Roman', serif;
  font-size: 1.125rem;
  font-weight: 400;
  line-height: 1.45;
  color: #000;
  transition: border-color var(--dur-fast) var(--ease-out);
}

.doc-toc-link:hover { color: #000; text-decoration: underline; text-underline-offset: 3px; }


.doc-toc-link.is-active {
  color: #000;
  border-left-color: var(--color-highlight);
}

.doc-toc-link .toc-num {
  font-family: var(--font-mono);
  font-size: 0.8125rem;
  font-weight: 400;
  color: #000;
  margin-right: 0.5em;
}


.doc-toc-item--sub .doc-toc-link {
  font-size: 0.9375rem;
  line-height: 1.5;
  padding-left: calc(var(--s-4) + var(--s-5));
  color: #000;
}


.doc-toc-toggle {
  display: none;
  align-items: center;
  gap: var(--s-2);
  padding: var(--s-3) var(--s-5);
  border-radius: var(--r-full);
  background: var(--glass-bg);
  backdrop-filter: blur(var(--glass-blur)) saturate(1.4);
  -webkit-backdrop-filter: blur(var(--glass-blur)) saturate(1.4);
  border: 1px solid var(--glass-border);
  color: var(--color-primary);
  font-family: inherit;
  font-size: var(--fs-sm);
  font-weight: var(--fw-semibold);
  cursor: pointer;
  transition: border-color var(--dur-fast) var(--ease-out);
}

.doc-toc-toggle:hover { border-color: var(--color-highlight); }

.doc-toc-toggle svg { width: 14px; height: 14px; transition: transform var(--dur-normal) var(--ease-out); }
.doc-toc-toggle[aria-expanded="true"] svg { transform: rotate(180deg); }



.doc-section {
  margin-top: clamp(64px, 9vw, 104px);
  padding-top: clamp(40px, 5vw, 56px);
  border-top: 1px solid var(--color-border-light);
}

.doc-article > .doc-section:first-child {
  margin-top: 0;
  padding-top: 0;
  border-top: none;
}

.doc-section-head {
  display: grid;
  grid-template-columns: auto 1fr;
  gap: var(--s-5);
  align-items: baseline;
  margin-bottom: var(--s-6);
}

.doc-section-num {
  font-family: 'Playfair Display', Georgia, serif;
  font-size: clamp(2.4rem, 4vw, 3.2rem);
  font-weight: var(--fw-black);
  line-height: 1;
  color: #000;
  opacity: 0.32;
  letter-spacing: -0.02em;
  transform: translateY(0.08em);
}

.doc-section-head h2 {
  font-family: 'Playfair Display', Georgia, serif;
  font-size: clamp(1.65rem, 2.6vw, 2.15rem);
  font-weight: var(--fw-bold);
  letter-spacing: -0.01em;
  line-height: 1.2;
  color: var(--color-text-primary);
}

.doc-section-desc {
  margin-top: var(--s-2);
  font-size: var(--fs-base);
  line-height: 1.6;
  color: var(--color-text-tertiary);
  font-weight: var(--fw-light);
  max-width: 56ch;
}



.doc-article p {
  font-size: 1.125rem;
  line-height: 1.85;
  color: #000;
  
  max-width: none;
  text-align: justify;
  margin-bottom: 1.4em;
}

.doc-article p:last-child { margin-bottom: 0; }

.doc-article strong {
  color: #000;
  font-weight: var(--fw-semibold);
}

.doc-article a {
  color: var(--color-primary-light);
  text-decoration: underline;
  text-decoration-color: rgba(143, 169, 74, 0.4);
  text-underline-offset: 3px;
}

.doc-article a:hover { color: var(--color-primary); }

.doc-article .term {
  font-weight: var(--fw-semibold);
  color: var(--color-primary);
}

.doc-article sup.cite {
  font-size: 0.62em;
  color: var(--color-highlight);
  font-weight: var(--fw-semibold);
  margin-left: 1px;
}


.gene {
  font-family: var(--font-mono);
  font-size: 0.86em;
  font-weight: 600;
  color: var(--color-primary);
  background: rgba(74, 89, 38, 0.08);
  padding: 0.1em 0.45em;
  border-radius: var(--r-sm);
  white-space: nowrap;
}


.doc-article h3 {
  font-family: 'Bitter', Georgia, 'Times New Roman', serif;
  font-size: 1.3rem;
  font-weight: var(--fw-bold);
  line-height: 1.35;
  color: var(--color-text-primary);
  margin: var(--s-8) 0 var(--s-4);
  padding-left: var(--s-4);
  border-left: 3px solid var(--color-highlight);
}

.doc-article h3:first-of-type { margin-top: var(--s-7); }

.doc-article h4 {
  font-family: var(--font-sans);
  font-size: 1.05rem;
  font-weight: var(--fw-semibold);
  color: var(--color-text-primary);
  margin: var(--s-6) 0 var(--s-3);
}

.doc-article ul:not(.doc-toc-list),
.doc-article ol {
  margin: 0 0 1.4em;
  padding-left: 1.4em;
  max-width: 66ch;
}

.doc-article li {
  font-size: 1.125rem;
  line-height: 1.8;
  color: #000;
  margin-bottom: var(--s-2);
}

.doc-article li::marker { color: var(--color-highlight); }


.doc-article [id] { scroll-margin-top: calc(var(--nav-h) + 28px); }



.doc-flow {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  gap: var(--s-2) var(--s-3);
  margin: var(--s-6) 0;
  padding: var(--s-5) var(--s-6);
  background: linear-gradient(135deg, rgba(74, 89, 38, 0.04) 0%, rgba(217, 237, 168, 0.1) 100%);
  border-radius: var(--r-lg);
}

.doc-flow-node {
  font-weight: var(--fw-bold);
  font-size: var(--fs-base);
  color: var(--color-primary);
  white-space: nowrap;
}

.doc-flow-node small {
  display: block;
  font-size: var(--fs-xs);
  font-weight: var(--fw-regular);
  color: var(--color-text-tertiary);
  letter-spacing: 0.02em;
}

.doc-flow-arrow {
  color: var(--color-highlight);
  font-size: var(--fs-lg);
  line-height: 1;
  transform: translateY(-0.35em);
}

.doc-flow-enzyme {
  font-size: var(--fs-xs);
  font-weight: var(--fw-semibold);
  color: var(--color-text-tertiary);
  transform: translateY(-0.35em);
}


.doc-overview-list {
  list-style: none;
  padding: 0 !important;
  margin: var(--s-6) 0 !important;
  max-width: none !important;
}

.doc-overview-list li {
  display: grid;
  grid-template-columns: auto 1fr;
  gap: var(--s-4);
  padding: var(--s-4) 0;
  border-top: 1px solid var(--color-border-light);
  margin-bottom: 0;
}

.doc-overview-list li:last-child { border-bottom: 1px solid var(--color-border-light); }

.doc-overview-num {
  font-family: 'Playfair Display', Georgia, serif;
  font-size: var(--fs-2xl);
  font-weight: var(--fw-black);
  line-height: 1.1;
  color: var(--color-highlight);
  opacity: 0.55;
  min-width: 2ch;
}

.doc-overview-list strong {
  display: block;
  font-size: var(--fs-base);
  margin-bottom: 2px;
}

.doc-overview-list p {
  font-size: var(--fs-sm);
  line-height: 1.65;
  margin: 0;
  max-width: none;
}



.note-card {
  margin: var(--s-6) 0;
  padding: var(--s-5) var(--s-6);
  background: var(--glass-bg);
  backdrop-filter: blur(var(--glass-blur)) saturate(1.4);
  -webkit-backdrop-filter: blur(var(--glass-blur)) saturate(1.4);
  border: 1px solid var(--glass-border);
  border-left: 3px solid var(--color-highlight);
  border-radius: var(--r-lg);
  box-shadow: var(--shadow-sm);
  max-width: 720px;
}

.note-card-tag {
  font-size: var(--fs-xs);
  font-weight: var(--fw-bold);
  text-transform: uppercase;
  letter-spacing: 0.18em;
  color: var(--color-highlight);
  margin-bottom: var(--s-3) !important;
}

.note-card p {
  font-size: var(--fs-sm);
  line-height: 1.7;
  margin-bottom: var(--s-2);
  max-width: none;
}

.note-card p:last-child { margin-bottom: 0; }

.note-card ul {
  margin: 0 !important;
  padding-left: 1.2em !important;
}

.note-card li {
  font-size: var(--fs-sm);
  line-height: 1.7;
  margin-bottom: var(--s-1);
}

.note-card--key { border-left-color: var(--color-highlight); }
.note-card--summary { border-left-color: var(--color-primary); }
.note-card--summary .note-card-tag { color: var(--color-primary); }

.note-card--warn { border-left-color: #b3592f; }
.note-card--warn .note-card-tag { color: #b3592f; }

.note-card--param dl {
  display: grid;
  grid-template-columns: auto 1fr;
  column-gap: var(--s-5);
  row-gap: var(--s-2);
  margin: 0;
}

.note-card--param dt {
  font-size: var(--fs-xs);
  font-weight: var(--fw-bold);
  text-transform: uppercase;
  letter-spacing: 0.08em;
  color: var(--color-text-tertiary);
  padding-top: 2px;
  white-space: nowrap;
}

.note-card--param dd {
  font-size: var(--fs-sm);
  line-height: 1.65;
  color: var(--color-text-secondary);
  margin: 0;
}



.figure {
  margin: var(--s-7) 0;
}

.figure-frame {
  background: #ffffff;
  border: 1px solid var(--color-border-light);
  border-radius: var(--r-lg);
  padding: clamp(10px, 1.6vw, 20px);
  box-shadow: var(--shadow-sm);
}

.figure-frame img,
.figure-frame video {
  width: 100%;
  height: auto;
  display: block;
  border-radius: calc(var(--r-lg) - 6px);
}

.figure figcaption {
  margin-top: var(--s-3);
  font-size: var(--fs-sm);
  line-height: 1.6;
  color: var(--color-text-tertiary);
  max-width: 68ch;
}

.figure-num {
  font-family: var(--font-mono);
  font-size: var(--fs-xs);
  font-weight: var(--fw-bold);
  text-transform: uppercase;
  letter-spacing: 0.1em;
  color: var(--color-highlight);
  margin-right: var(--s-2);
}


.figure--wide {
  width: min(920px, calc(100vw - 2 * clamp(20px, 4vw, 48px)));
  margin-left: 50%;
  translate: -50% 0;
}


.figure--full {
  width: 100vw;
  margin-left: 50%;
  translate: -50% 0;
}

.figure--full .figure-frame { border-radius: 0; border-inline: none; }


.figure-pair,
.figure-gallery {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: var(--s-5);
  margin: var(--s-7) 0;
}

.figure-pair .figure,
.figure-gallery .figure { margin: 0; }

.doc-article { counter-reset: docfigure; }

.figure-group {
  counter-increment: docfigure;
  margin: var(--s-7) 0;
}

.figure-group .figure-frame { padding: clamp(12px, 1.8vw, 24px); }

.figure-grid {
  display: grid;
  grid-template-columns: 1fr;
  gap: var(--s-5);
}

.figure-item {
  display: flex;
  flex-direction: column;
  gap: var(--s-2);
}

.figure-item img {
  width: 100%;
  height: auto;
  display: block;
}

.figure-item-label {
  align-self: center;
  font-family: var(--font-mono);
  font-size: var(--fs-sm);
  font-weight: var(--fw-semibold);
  color: #000;
  letter-spacing: 0.05em;
}

.figure-group figcaption {
  margin-top: var(--s-4);
  font-size: 0.9375rem;
  line-height: 1.7;
  color: #000;
}



.figure-group .figure-num {
  font-family: inherit;
  font-size: inherit;
  font-weight: 700;
  text-transform: none;
  letter-spacing: normal;
  color: #000;
  margin-right: 0;
}

.figure-group .figure-num::before {
  content: "Figure " counter(docfigure) ".";
  margin-right: 0.4em;
}



.doc-article .table-scroll {
  overflow-x: auto;
  margin: var(--s-6) 0;
  -webkit-overflow-scrolling: touch;
}

.doc-article table {
  width: 100%;
  border-collapse: collapse;
  font-size: 0.9375rem;
  line-height: 1.65;
  color: #000;
}

.doc-article th,
.doc-article td {
  border: 1px solid rgba(0, 0, 0, 0.3);
  padding: 0.55em 0.75em;
  text-align: left;
  vertical-align: top;
}

.doc-article th {
  font-weight: var(--fw-bold);
  background: rgba(74, 89, 38, 0.07);
  white-space: nowrap;
}



.doc-reveal {
  opacity: 0;
  translate: 0 22px;
  transition: opacity 0.7s var(--ease-out), translate 0.7s var(--ease-out);
}

.doc-reveal.is-visible {
  opacity: 1;
  translate: 0 0;
}



@media (max-width: 1199px) {
  .doc-layout { grid-template-columns: 200px minmax(0, 1fr); }
  .doc-article { max-width: 660px; }
}

@media (max-width: 1023px) {
  .doc-layout {
    grid-template-columns: minmax(0, 1fr);
    gap: 0;
  }

  .doc-toc-toggle { display: inline-flex; }

  .doc-toc {
    display: none;
    position: static;
    max-height: none;
    margin: var(--s-6) 0 var(--s-7);
    padding: var(--s-5) var(--s-6);
    background: var(--glass-bg);
    backdrop-filter: blur(var(--glass-blur)) saturate(1.4);
    -webkit-backdrop-filter: blur(var(--glass-blur)) saturate(1.4);
    border: 1px solid var(--glass-border);
    border-radius: var(--r-lg);
  }

  .doc-toc.doc-toc--open { display: block; animation: toc-in 0.35s var(--ease-out); }
  .doc-toc.doc-toc--open .doc-toc-list { max-height: 52vh; overflow-y: auto; }
}

@keyframes toc-in {
  from { opacity: 0; translate: 0 -8px; }
  to { opacity: 1; translate: 0 0; }
}

@media (max-width: 768px) {
  .doc-article p,
  .doc-article li { font-size: 1.0625rem; }

  .doc-article h3 {
    font-size: 1.15rem;
    margin-top: var(--s-7);
  }

  .doc-section-head {
    grid-template-columns: 1fr;
    gap: var(--s-2);
  }

  .doc-section-num { font-size: 2.1rem; }

  .doc-flow {
    flex-direction: column;
    align-items: flex-start;
    gap: var(--s-3);
    padding: var(--s-4) var(--s-5);
  }

  .doc-flow-arrow,
  .doc-flow-enzyme { transform: none; }

  .doc-flow-arrow { rotate: 90deg; }

  .figure-pair,
  .figure-gallery { grid-template-columns: 1fr; }

  .note-card--param dl { grid-template-columns: 1fr; row-gap: var(--s-1); }
  .note-card--param dt { padding-top: var(--s-2); }
}

@media (max-width: 430px) {
  .doc-article p,
  .doc-article li { font-size: 1rem; }

  .figure--wide {
    width: calc(100vw - 2 * clamp(20px, 4vw, 48px));
  }

  .figure-frame { padding: 8px; }

  .doc-overview-list li { grid-template-columns: auto 1fr; gap: var(--s-3); }
}



@media (prefers-reduced-motion: reduce) {
  .doc-reveal {
    opacity: 1;
    translate: none;
    transition: none;
  }
  .doc-toc.doc-toc--open { animation: none; }
  .doc-toc-toggle svg { transition: none; }
}